Ingredients - COS Pellets*

COS™ Pellets is a revolutionary formulation  of  Hyaluronic Acid, Silicon Dioxide, Amino Acids, minerals, vitamins and  micro-sized isolates (precursors to the active ingredients found in Chondroitin , Glucosamine and MSM). 

Micro-sized isolates participate in the chemical reactions of Chondroitin, Glucosamine and MSM for better assimilation and absorption of the active ingredients.  The small micro-sized isolates penetrate the cellular walls more efficiently than larger one, providing quicker and more effective nourishment to joints and bone.  COS™ Pellets do not rely on the large and difficult molecules for absorption but on the technology of micro-sized molecules (Isolates) for a superior assimilation and utilization of active ingredients necessary for healthy bone and joints for dogs.  (Read More)

Active Ingredients per 4 gram measure (scoop)

Sulfur 2mg   Hyaluronic Acid 5.6mg
Vitamin B-6 4.4mg   Proline 12.4mg
Glycine 40mg   Manganese Sulfate 20mg
Gelatin 44mg   Vitamin C 80mg
Glutamine 40mg   Zinc Oxide 60mg
Silicon Dioxide (Silica) 118mg      

*Contains Yeast Culture, Cellulose, Dicalcium Phosphate, Vegetable Oil, Natural Flavor

Amino Acids and Collagen

Amino Acids and Collagen are the chemical units or "building blocks" of the body that make up proteins.  Growth, repair and maintenance of all cells are dependent upon these proteins.   After the protein is made from a pool of Amino Acids, it can be used to serve a particular purpose.  Collagen is the most common protein in the body and make up approximately 20-30% of all body proteins. Collagen functions are very different compared to other types of proteins.  Bones are made by adding mineral crystals to Collagen (protein) and makes up more than 90% of the bone matrix.  Since Amino Acids are so important to make protein and the Collagen protein is so important for the bone development, deficiencies can be problematic for bone development.

Proline Isolates

(micro-sized Isolates comparable to the active ingredients of Chondroitin.) An Amino Acid that helps produces heals, strengthen and reduce the loss of collagen with age.  Collagen production decreases significantly with age and is the source of serious degenerative bone diseases.  Proline’s relationship with collagen combats harmful enzymes that break down cartilage and for that reason it helps prevent bone loss in osteoporosis. Proline Isolates like Chondroitin promote the formation of bone and cartilage, increase flexibility, cushion the joint and prevent cartilage degeneration.  Proline is extremely important for the proper functioning of joints and tendons.


(micro-sized Isolate comparable to the active ingredients of Chondroitin) an Amino Acid that plays an important role in cartilage which turns into bone.  Glycine forms almost 1/3 of Collagen.  Cellular Metabolism Institute in Tenerife and the Department of Biochemistry and Molecular Biology of the University of Granada established that Glycine helps prevent Arthrosis (inflammation of the joint), osteoporosis and other degenerative diseases.  Carnivores naturally consume Gelatin and its primary amino acid, Glycine, in the skin, tendons and cartilage of their prey. Since most pet dogs do not eat skin, tendons and cartilage, some researchers speculate that Glycine deficiency is responsible for many cases of arthritis.

Glutamine Isolate

(micro-sized Isolates comparable to the active ingredients of Glucosamine) the chemical synthesis of glucose (dextrose) with Glutamine produces Glucosamine.   It is a precursor for Glycosaminoglycans, a major component of the joint cartilage and when linked to core proteins, forms Proteoglycans.  Proteoglycans play important roles in organizing the bone extracellular matrix, taking part in the structuring of the tissue itself as active regulators of Collagen. Glucosamine nourishes joints because is involved in the production of cartilage and synovial fluid, and may help replenish depleted or damaged tissues. It has been shown to have anti-inflammatory properties and may protect against development of atherosclerosis.


(micro-sized Isolate comparable to the active ingredients of MSM).   MSM is a natural source of Sulfur and necessary for the production of Collagen. Glucosamine and Chondroitin help incorporate the sulfur into cartilage.  Sulfur is the dominant component of connective tissue and bone and acts as a binder to improve bone density.  Sulfur is important to maintain joint health and improve bone density. Sulfur helps build cartilage, tendon and bone. 

Hyaluronic Acid

Hyaluronic Acid is a major component of synovial fluid that surrounds joints.  It is a naturally occurring compound in your dog’s body.  It is a Glycosaminoglycan (large protein molecule) that acts like a sponge to hold water giving connective tissues elasticity and producing cushioning effects.  Hyaluronic acid plays an integral role in maintaining and regulating moisture.  Hyaluronic Acid assists in the distribution of nutrients to cells that don’t possess a good blood supply, such as cartilage, and plays a role in the removal of metabolic waste.   HA helps joints have resiliency, ease of movement, and cushioning like a shock absorber.  Without adequate Hyaluronic Acid, cartilage deteriorates.  Optimum levels of Hyaluronic Acid are essential for the health of the joints and cartilage.


Gelatin is high in the non-essential amino acids Glycine and Proline.  Gelatin has also been claimed to promote general joint health.   A study at Ball State University sponsored by Nabisco, the former parent company of Knox gelatin, found that Gelatin supplementation relieved knee joint pain and stiffness in athletes.

Vitamin B-6

Vitamin B-6 benefits your body in multiple ways. It is involved in almost 100 different chemical reactions in your body per minute.  It functions mostly as a co-enzyme - Vitamin B6 works with other enzymes to regulate all sorts of processes in your body.  Vitamin B6 is an essential nutrient required for the metabolism of lipids, carbohydrates, and proteins.  It facilitates the conversion of amino acids necessary for bone development from one to another as needed.

Manganese Sulfate

Manganese Sulfate is a mineral predominantly stored in the bones which aids in bone metabolism but is most helpful in combination with other minerals.  Because Manganese plays a role in bone metabolism with minerals, it has been suggested as a treatment for osteoporosis and osteoarthritis.

Zinc Oxide

Zinc Oxide is an inorganic compound considered to be of a mineral.  Zinc is an essential mineral that play an important role in most metabolic pathways.  Zinc is vital for maintenance of healthy bone mass by activating crucial enzymes.  Low Zinc intake appears to be linked to lower bone mass.

Vitamin C

Vitamin C (ascorbic acid) is a water-soluble vitamin necessary in the body to form collagen in bones and cartilage.  Without Vitamin C the synthesized collagen is too unstable for the formation of cartilage and bones.  Vitamin C is very important for osteoblast (bone formation) and helps with absorption of Hyaluronic Acid.

Silicon dioxide or silica

Silicon dioxide or silica is a trace mineral found in bones, formed by the combination of Silicon and oxygen.  Silicon helps get the bone growth process started, and continues bone mineralization.  Silicon compounds were also shown in vitro to stimulate the DNA synthesis in osteoblast (bone building).  Based on current clinical data, Silicon is being considered a critical nutrient to better manage the effects and healing of OCD and prevent osteoporosis.

*This product is manufactured in the USA and all ingredients are purchased from USA registered companies.